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愛知医科大学

© Division of ALS Research, Aichi Medical University

研究業績Publications

論文、総説、特許など

2023年

  1. Oral Edaravone - Introducing a Flexible Treatment Option for Amyotrophic Lateral Sclerosis
    Pattee GL, Genge A, Couratier P, Lunetta C, Sobue G, Aoki M, Yoshino H, Jackson CE, Wymer J, Salah A, Nelson S.
    Expert Rev Neurother. 2023/8/30
  2. Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients
    Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group.
    J Neurol Neurosurg Psychiatry. 2023/5/4
  3. Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice
    Takeuchi T, Maeta K, Ding X, Oe Y, Takeda A, Inoue M, Nagano S, Fujihara T, Matsuda S, Ishigaki S, Sahashi K, Minakawa EN, Mochizuki H, Neya M, Sobue G, Nagai Y.
    Mol Ther Nucleic Acids. 2023/2/23
  4. An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study
    Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K, Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M, Izumi Y.
    JMIR Res Protoc. 2023/1/30

2022年

  1. TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
    Riku Y, Yoshida M, Iwasaki Y, Sobue G, Katsuno M, Ishigaki S.
    Int J Mol Sci. 2022/12/23
  2. The SYNGAP1 3'UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPK
    Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G.
    J Neurosci. 2022/10/19
  3. Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
    Miller TM, Cudkowicz ME, Genge A, Shaw PJ, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Cochrane T, Chary S, Chew S, Zhu H, Wu F, Nestorov I, Graham D, Sun P, McNeill M, Fanning L, Ferguson TA, Fradette S; VALOR and OLE Working Group.
    N Engl J Med. 2022/9/21
  4. Amyotrophic lateral sclerosis
    Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, Sobue G.
    Lancet. 2022/9/18
  5. Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study
    Ohdake R, Watanabe H, Kawabata K, Ogura A, Sato M, Tanaka Y, Imai K, Masuda M, Kato T, Yokoi T, Hara K, Nakamura R, Atsuta N, Nakagawa M, Katsuno M, Sobue G.
    Arch Clin Neuropsychol. 2022/8/25
  6. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial
    Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S, Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K, Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K, Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators.
    JAMA Neurol. 2022/5/9
  7. Safety and Clinical Benefits of Laryngeal Closure in Patients with Amyotrophic Lateral Sclerosis
    Yokoi S, Nishio N, Maruo T, Hiramatsu M, Mukoyama N, Tsuzuki H, Wada A, Atsuta N, Ito D, Tsuboi T, Sobue G, Katsuno M, Fujimoto Y, Sone M.
    Dysphagia. 2022/5/4
  8. Serum asymmetric dimethylarginine level correlates with the progression and prognosis of amyotrophic lateral sclerosis
    Ikenaka K, Maeda Y, Hotta Y, Nagano S, Yamada S, Ito D, Torii R, Kakuda K, Tatebe H, Atsuta N, Aguirre C, Kimura Y, Baba K, Tokuda T, Katsuno M, Kimura K, Sobue G, Mochizuki H.
    Eur J Neurol. 2022/2/7
  9. Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis
    Tohnai G, Nakamura R, Atsuta N, Nakatochi M, Hayashi N, Ito D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Ishihara T, Kawata A, Yokota T, Hasegawa K, Nagano I, Yabe I, Tanaka F, Kuru S, Hattori N, Nakashima K, Kaji R, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).
    Neurobiol Aging. 2022/1/18

2021年

  1. Unexpected postmortem diagnoses in cases of clinically diagnosed amyotrophic lateral sclerosis
    Riku Y, Yoshida M, Tamura T, Kamijo M, Yasui K, Kameyama T, Katsuno M, Sobue G, Iwasaki Y.
    Neuropathology. 2021/11/16
  2. Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis
    Ogura A, Kawabata K, Watanabe H, Choy SW, Bagarinao E, Kato T, Imai K, Masuda M, Ohdake R, Hara K, Nakamura R, Atsuta N, Nakamura T, Katsuno M, Sobue G.
    Eur J Neurol. 2021/10/11
  3. Randomized phase 2 study of perampanel for sporadic amyotrophic lateral sclerosis
    Aizawa H, Kato H, Oba K, Kawahara T, Okubo Y, Saito T, Naito M, Urushitani M, Tamaoka A, Nakamagoe K, Ishii K, Kanda T, Katsuno M, Atsuta N, Maeda Y, Nagai M, Nishiyama K, Ishiura H, Toda T, Kawata A, Abe K, Yabe I, Takahashi-Iwata I, Sasaki H, Warita H, Aoki M, Sobue G, Mizusawa H, Matsuyama Y, Haga T, Kwak S.
    J Neurol. 2021/6/30​​​​​​​
  4. Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
    Riku Y, Seilhean D, Duyckaerts C, Boluda S, Iguchi Y, Ishigaki S, Iwasaki Y, Yoshida M, Sobue G, Katsuno M.
    Int J Mol Sci. 2021/4/30​​​​​​​
  5. Clinicoradiological features in amyotrophic lateral sclerosis patients with olfactory dysfunction
    Masuda M, Watanabe H, Ogura A, Ohdake R, Kato T, Kawabata K, Hara K, Nakamura R, Atsuta N, Epifanio B, Katsuno M, Sobue G.
    Amyotroph Lateral Scler Frontotemporal Degener. 2021/4/28

2020年以前

  1. A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis
    Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Okada Y, Ishihara T, Onodera O, Nakashima K, Kaji R, Kamatani Y, Ikegawa S, Momozawa Y, Kubo M, Ishida N, Minegishi N, Nagasaki M, Sobue G.
    Commun Biol. 2020/9/24
  2. Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis
    Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Hattori N, Nakashima K, Kaji R, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).
    Neurobiol Aging. 2020/9/5
  3. Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases
    Ishigaki S, Riku Y, Fujioka Y, Endo K, Iwade N, Kawai K, Ishibashi M, Yokoi S, Katsuno M, Watanabe H, Mori K, Akagi A, Yokota O, Terada S, Kawakami I, Suzuki N, Warita H, Aoki M, Yoshida M, Sobue G.
    Brain. 2020/8/10
  4. ALS is a multistep process in South Korean, Japanese, and Australian patients
    Vucic S, Higashihara M, Sobue G, Atsuta N, Doi Y, Kuwabara S, Kim SH, Kim I, Oh KW, Park J, Kim EM, Talman P, Menon P, Kiernan MC; PACTALS Consortium.
    Neurology. 2020/2/20
  5. Prognosis of amyotrophic lateral sclerosis patients undergoing tracheostomy invasive ventilation therapy in Japan
    Hayashi N, Atsuta N, Yokoi D, Nakamura R, Nakatochi M, Katsuno M, Izumi Y, Kanai K, Hattori N, Taniguchi A, Morita M, Kano O, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Aiba I, Mizoguchi K, Oda M, Kaji R, Sobue G.
    J Neurol Neurosurg Psychiatry. 2020/1/16
  6. Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement
    Ogura A, Watanabe H, Kawabata K, Ohdake R, Tanaka Y, Masuda M, Kato T, Imai K, Yokoi T, Hara K, Bagarinao E, Riku Y, Nakamura R, Kawai Y, Nakatochi M, Atsuta N, Katsuno M, Sobue G.
    EBioMedicine. 2019/9/8​​​​​​​
  7. Increase of arginine dimethylation correlates with the progression and prognosis of ALS
    Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G.
    Neurology. 2019/3/15​​​​​​​
  8. Age-related impairment in Addenbrooke's cognitive examination revised scores in patients with amyotrophic lateral sclerosis
    Masuda M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G.
    ​​​​​​​Amyotroph Lateral Scler Frontotemporal Degener. 2018/11/1​​​​​​​
  9. Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
    Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
    Nat Med. 2018/8/22
  10. Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility
    Tanikawa C, Ueda K, Suzuki A, Iida A, Nakamura R, Atsuta N, Tohnai G, Sobue G, Saichi N, Momozawa Y, Kamatani Y, Kubo M, Yamamoto K, Nakamura Y, Matsuda K.
    Cell Rep. 2018/2/10​​​​​​​
  11. Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis
    Tohnai G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, Kuwabara S, Abe K, Aiba I, Okamoto K, Mizoguchi K, Hasegawa K, Aoki M, Hattori N, Onodera O, Naruse H, Mitsui J, Takahashi Y, Goto J, Ishiura H, Morishita S, Yoshimura J, Doi K, Tsuji S, Nakashima K, Kaji R, Atsuta N, Sobue G; Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).
    Neurobiol Aging. 2018/2/6​​​​​​​
  12. 3'UTR Length-Dependent Control of SynGAP Isoform α2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function
    Yokoi S, Udagawa T, Fujioka Y, Honda D, Okado H, Watanabe H, Katsuno M, Ishigaki S, Sobue G.
    Cell Rep. 2017/9/28